MBP® - Bone Health
MBP® is a whey protein fraction designed to support bone density maintenance and bone health.
Supported by mechanistic studies and by human clinical studies conducted in Asian women, MBP® has demonstrated an increase in bone mineral density. 40 mg/day.
MBP® - Key features
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Whey protein fraction
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Designed to support bone density maintenance and overall bone health
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Contributes to skeletal strength by helping maintain bone mineral density
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Supports biomarkers associated with healthy bone metabolism.
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Effects on bone metabolism parameters observed from 3 months
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Bone mineral density changes observed after 6 months
Science supporting MBP®
MBP® is supported by mechanistic studies exploring its role in bone metabolism and by human clinical studies conducted in Asian women aged 20 to 86 years. The double‑blind, randomised, placebo‑controlled clinical studies have evaluated bone mineral density and bone metabolism–related parameters across different life stages, while more than ten peer‑reviewed publications provide supporting evidence on MBP®’s mechanism of action.
Characterisation
MBP is a coproduct of the manufacturing of lactoferrin, obtained by chromatography on ion exchange resin and being released at basic pH, Milk Basic Protein.
Bioactive compounds
Protein content ≥ 93%
incl. Lactoferrin 45%-60%
CPI activity ≥ 22 mU/mg
Composition: Whey fraction from skimmed cow milk
Recommended daily dosage: 40 mg
Clinically supported benefits
Double-blind, randomised, placebo-controlled studies.
| LOCATIONS |
Japan Kagawa Nutrition University |
Japan Kagawa Nutrition University |
Japan Kagawa Nutrition University |
Japan Kagawa Nutrition University |
| YEAR & DURATION | 2007 6 months |
2001 6 months |
2005 6 months |
2010 12 months |
| POPULATIONS |
20-23 years old
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20-37 years old
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20-23 years old Onset menopause |
65-86 years old Post-menopause |
| INTAKES |
40 mg/day in 50 ml of water |
40 mg/day in 50 ml of water | 40 mg/day in 50 ml of water | 40 mg/day in 50 ml of water |
PROTOCOLS:
- Measure of blood and urine biomarkers of bone metabolism
- Measure of bone mineral density by DXA scan
- Usual diet
- No supplementation in vitamin D or calcium
Bone mineral density
Clinical studies with MBP® have shown potential to support spine bone mineral density over a 6‑month supplementation period.
In these studies, the impact of MBP® on bone mineral density was assessed at a reference skeletal site commonly used in bone health research, the lumbar spine (L2–L4).
Supplementation with 40 mg of MBP® per day for 6 months was associated with increases in lumbar spine bone mineral density, with reported changes of +1.44% in young adults (20s) and +1.87% in women at the onset of menopause.
Observations at additional skeletal sites
Beyond the lumbar spine, MBP® has also been investigated for its impact on bone mineral density at other skeletal sites.
In a study conducted in 33 women (mean age 28.8 ± 8.7 years), MBP® supplementation was associated with improvements in radial and calcaneal bone mineral density, suggesting a broader involvement in bone density–related parameters.
MBP® is safe
No adverse event linked to MBP® supplementation has been recorded.
Certifications & Compliance
Non-GMO, Halal, Kosher, gluten-free, suitable for vegetarians.
GRAS status - Notice No. GRN 000196
Japanese FOSHU registration 1276: "This product with MBP, which is effective to increase bone density, is suitable for people conscious of bone health"
South Korea Health Ingredient registration 2015-16: "May help to maintain healthy bone"
Australia / New Zealand - Claims available for food products: maintenance of normal bones/healthy bones // maintenance of bone mineralisation // maintenance of bone mineral density
References
MECHANISTIC STUDIES
Takada et al.; BBRC; 1995
Takada et al.; Int. Dairy Journal; 1997
Yamamura et al; BBRC; 1999
Yamamura et al.; BBRC; 2000
Takada et al.; Nutr. Aspec. Osteoporosis; 2001
Toba et al;Bone; 2001
Matsuoka et al.; Biosci. Biotechnol. Biochem.; 2002
CLINICAL TRIALS
Aoe et al; Osteoporosis Int; 2005
Uenishi et al; Osteoporosis Int; 2007
Aoe et al; Biosci. Biotechnol. Biochem; 2001
Yamamura et al; Biosci. Biotechnol. Biochem; 2002
This website is intended to provide information about Biotexia’s ingredients, used in various food/dietary supplement products around the world. It is only intended for business to business and to provide information to food/dietary supplement professionals and is not designed for the general public. Statements used on this website have not been evaluated by competent authority. Products are not intended to diagnose, treat, cure or prevent any disease.
