Careflow® - Microcirculation
Careflow® is a patented, organic and standardised mango fruit powder shown to support normal blood flow and microvascular function. Through activation of key metabolic enzymes such as eNOS and SIRT1, Careflow® helps promote normal endothelial activity and microcirculation. Supported by both acute and chronic published clinical trials. 100 mg/day.
Careflow® - Key features
- Patented, organic, and standardised mango fruit powder
- Activates SIRT1 and eNOS, key metabolic enzymes
- Helps support normal blood flow and healthy microcirculation
- Demonstrates microcirculation benefits from the first intake
- Improved microvascular function after one month of supplementation
Science supporting Careflow®
Careflow® acts by modulating SIRT1 and activating eNOS, two key enzymes involved in endothelial function and nitric‑oxide–mediated microvascular regulation. Its ability to support healthy blood flow and microcirculation has been demonstrated in both acute and chronic gold‑standard clinical trials.
Characterisation
Careflow® is a standardised whole fruit powder of mango Mangifera indica L. obtained from the subspecies Totapuri (a.k.a. Kili-Mooku). It is cultivated in the Tamil Nadu region of India, at a specific degree of maturity, when the content of secondary plant compounds is high.
Bioactive compounds
Mangiferin ≥ 0.03%
Composition: Mango fruit powder (Mangifera indica (L.) spp. Totapuri)
Recommended daily dosage: 100 mg/day
Clinically supported benefits
Double-blind, randomised, placebo-controlled studies.
|
LOCATIONS |
BioTeSys GmbH, Germany |
BioTeSys GmbH, Germany |
|
YEAR & DURATION |
2015 |
2017 |
|
POPULATIONS |
10 subjects |
75 subjects |
|
PROTOCOLS |
Blood flow & oxygen circulation |
Microcirculation |
| INTAKES |
SACHETS |
SACHETS 100 mg/day of Careflow in water |
Microcirculation
Relative blood flow is a recognised parameter used to assess microcirculation in acute clinical studies.
In an acute study setting, changes in relative blood flow were observed following intake of Careflow®, compared with baseline measurements. The time course of these changes was assessed up to 6 hours after intake, within the study conditions.
At a daily intake of 100 mg, an increase in relative blood flow compared with baseline was reported in the study population.
Vascular function
Reactive hyperaemia flow (RH‑flow) is commonly used to evaluate microcirculation in long‑term clinical studies.
After 4 weeks of supplementation with 100 mg of Careflow®, changes in RH‑flow and microvascular responsiveness were observed, compared with baseline values, as measured within the clinical study framework.
Careflow® is safe.
No adverse event linked to Careflow® supplementation has been recorded.
Certifications & Compliance
Organic certified
Non-GMO, Halal, Kosher, gluten-free, suitable for vegetarians
References
MECHANISTIC STUDIES
Röchter S. et al. Agro Food Industry Hi-Tech. 2015; Vol. 26(3)
Gerstgrasser A. et al. Planta Med. 2015; 82(4), 298-304
CLINICAL TRIALS
Buchwald-Werner S. et al. Planta Med. 2017; 83(10): 824-829
Gerstgrasser A. et al. Planta Med. 2015; 82(4), 298-304
This website is intended to provide information about Biotexia’s ingredients, used in various food/dietary supplement products around the world. It is only intended for business to business and to provide information to food/dietary supplement professionals and is not designed for the general public. Statements used on this website have not been evaluated by competent authority. Products are not intended to diagnose, treat, cure or prevent any disease.
